Virulence of Burkholderia mallei Quorum-Sensing Mutants
نویسندگان
چکیده
منابع مشابه
Virulence of Burkholderia mallei quorum-sensing mutants.
Many Proteobacteria use acyl-homoserine lactone-mediated quorum-sensing (QS) to activate specific sets of genes as a function of cell density. QS often controls the virulence of pathogenic species, and in fact a previous study indicated that QS was important for Burkholderia mallei mouse lung infections. To gain in-depth information on the role of QS in B. mallei virulence, we constructed and c...
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Acyl-homoserine lactones (HSLs) serve as quorum-sensing signals for many Proteobacteria. Members of the LuxI family of signal generators catalyze the production of acyl-HSLs, which bind to a cognate receptor in the LuxR family of transcription factors. The obligate animal pathogen Burkholderia mallei produces several acyl-HSLs, and the B. mallei genome has four luxR and two luxI homologs, each ...
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The following individuals read and discussed the thesis submitted by student Aubrey N. Montebello, and they evaluated her presentation and response to questions during the final oral examination. They found that the student passed the final oral examination. iv DEDICATION I dedicate this work to my supportive and loving friends and family. Their constant encouragement was a blessing during the ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2013
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00048-13